BRAND NAME: Neurontin
GENERIC NAME: Gabapentin
Capsules: 1 caps. – 100 mg, 300 mg, 400 mg
Tablets: 1 tabl- 600 mg, 800 mg
Medical uses of Neurontin
- Neurontin is an anticonvulsant or antiepileptic drug. It is widely used in combination with other drugs to prevent seizures.
- Neurontin treats different kinds of neuropathic pain such as trigeminal neuralgia, peripheral neuropathy, diabetic and alcoholic neuropathy, and restless legs syndrome but Neurontin can be used in these cases only if the drug has been prescribed by the specialist.
- It is also used in a complex regional pain syndrome (vibration disease), postherpetic neuralgia, metastatic affection of the spine, radiculopathy, and postlaminectomy syndrome.
Benefits of Neurontin (Gabapentin)
The appearance of a new drug Neurontin (Gabapentin) has opened new prospects in the treatment of neuropathic pain and a host of other chronic pain syndromes. The point of application of Gabapentin is voltage-dependent calcium N-channels located in the surface plate of the posterior horn, which explains the antiallodynic effect of Gabapentin. Main advantages of Neurontin (Gabapentin) include:
- an excellent pharmacokinetic profile: it is not metabolized, does not bind to plasma proteins, is excreted by the kidneys, and easily penetrates the BBB. The favorable profile of the pharmacokinetics of Gabapentine makes it a good choice for the treatment of elderly patients receiving polypharmacy and provides a high level of safety of the drug.
- in addition, Gabapentin has no effect on hepatic enzymes, and drugs that affect hepatic enzyme activity do not affect the pharmacokinetics of Gabapentin.
- no need for monitoring the concentration of the drug in the blood.
- a mild profile of side effects (sedation and dizziness may occur).
It is important to know before taking Neurontin
- Signs of the serious interaction of Neurontin with other drugs are not observed. However, one should refrain from using it in combination with alcohol, tranquilizers, antihistamines, barbiturates, anticonvulsants, sleeping pills, and muscle relaxants.
- The combination of Gabapentin with lidocaine or antidepressants enhances its effect. Therefore, it makes sense to combine it with the Versasitis patch containing lidocaine, with Tolperisone (midocalm), the molecule of which has a lidocaine-like effect, so the appointment of midocalm in a dose of 300-450 mg per day potentiates the action of Gabapentin in the treatment of neuropathic pain syndromes.
- The concentration of Gabapentin in plasma reaches a peak 2-3 h after administration. The dosing interval should not exceed 12 hours.
- Bioavailability of Neurontin is 60%.
- The intake of food does not affect the pharmacokinetics of Neurontin.
- Antacids reduce the concentration of gabapentin in the blood, so it is recommended to take it no earlier than 2 hours after taking antacids. The drug is excreted mainly by the kidneys and is not metabolized in the liver.
- If the kidney function is disrupted, the dose of Neurontin is selected taking into account the clearance of creatinine.
EXAMPLES OF THE USE OF NEURONTIN IN THE TREATMENT OF THE NEUROPATHIC PAIN SYNDROME
- The recommended maximum dose is 1800-2400 mg/day.
- Treatment begins with a dose of 300 mg/day, which is increased to the recommended level during the first week.
- The course of treatment is 2-4 months.
- The dose of Neurontin is 1800-3600 mg/day (initial 300 mg).
- Treatment continues for 2-4 months.
Pain in multiple sclerosis
- The initial dose of the drug is 300 mg/day.
- It is increased to 900 mg/day or more for 3 weeks.
- The average dose is 900 mg/day.
- Treatment continues for 2-4 months.
Trigeminal neuralgia In many studies, Gabapentin was effective in patients with trigeminal neuralgia that did not respond to treatment with other drugs (carbamazepine, phenytoin, valproate, amitriptyline, and various non-steroidal anti-inflammatory drugs). There was complete relief of pain in most cases.