Imitrex

DRUG FORMS

Tablets of 100 mg (0.1 g), ampoules of 0.5 ml with 6 mg (0.06 g) of the preparation.

Imitrex is a new revolutionary drug for the treatment of the acute migraine pain.

Imitrex (Sumatriptan) is a recently developed drug for the treatment of a migraine. Having received such a powerful drug as Sumatriptan, doctors made a revolution in the treatment of acute migraine attacks. Sumatriptan is considered to be the “gold standard” in the acute management of a migraine headache. Its clinical effectiveness is associated with the ability to narrow the dilated cranial vessels and/or block the release of the peptide associated with the calcitonin gene (CGRP) and the P (SP) substance from the trigeminovascular afferents. Sumatriptan stops a headache and associated manifestations in 74-83% of cases four hours after ingestion and two hours after intranasal and subcutaneous administration of the drug.

Imitrex very quickly removes the headache in the case of a migraine attack but only if you really have a migraine, and not some other headache.

How does a migraine differ from other types of a headache:

– a “classic” migraine attack regularly occurs 1-3 times a month: there is a strong, sharp headache in the temples or near the eye, sometimes on the forehead;
– pain can be in the ear or back of the head;
– only one half of the head usually hurts when experiencing migraine;
– an attack lasts from 2 to 48 hours; the pain at the time of the attack is so strong that you cannot even stir.

Mechanism of action of Imitrex

The mechanism of action of Imitrex is associated with its effect on serotonin (5-HT) receptors in the brain. It is shown that it is a selective agonist of 5-HT1D receptors (the drug has a close structural similarity with serotonin), stimulation of which reduces the pulsation of cerebral vessels and the associated headache. Imitrex also decreases the release of neuropeptides and other mediators of inflammation. Sumatriptan does not affect adrenergic, dopaminergic, muscarinic, and benzodiazepine receptors.

  • It relieves migraine headaches (with or without aura) in persons who do not respond to non-narcotic analgesics and non-steroidal anti-inflammatory drugs.
  • It also reduces vomiting, nausea, photophobia, and other phenomena associated with an inherent migraine.
  • It can be prescribed prophylactically in the case of the frequent migraine attacks but not for a long time.

How is Imitrex taken?

When taken orally and subcutaneously, the drug is rapidly absorbed. Action for oral administration begins after about 10 minutes (relief of a headache); vomiting, nausea, and photophobia go away in 20 minutes.

–           It is administered orally first at a dose of 0.1 g (100 mg); if the effect is insufficient, the drug is re-administered at the same dose after 4 hours (no more than 3 times a day).
–           Imitrex is administered subcutaneously (thighs or forearms) at a dose of 0.06 g (6 mg); the reception can be repeated in the same dose after 1 hour. If poorly tolerated, it is injected in a smaller dose.

Common side effects

When using Imitrex, there may be the heart pain (usually without ischemia), chest pressure, difficulty swallowing, muscle pain. As well, there may be allergic reactions and other side effects that occur on their own.

It is important to know:

  1. Imitrex is contraindicated in patients who have or had ischemic bowel disease, coronary heart disease and vasospasm, uncontrolled arterial hypertension, diseases of peripheral vessels, and basilar or hemiplegic migraine.
  2. Sumatriptan and its analogs are not intended for use for the preventive purposes. They are taken only at the time of the attack!
  3. If migraine symptoms do not disappear after taking the first dose of Imitrex (Sumatriptan), then the drug is not used again to stop the same attack. However, to relieve the following migraine attacks, the second dose of the drug can be taken. The interval between admission should be at least 2 hours. The maximum daily dose of Imitrex is 300 mg.
  4. Imitrex should not be used simultaneously with MAO inhibitors (antidepressants, furazolidone, procarbazine, selegiline), antidepressants – inhibitors of the neuronal seizure of serotonin.